Targeted Therapy for Cancer | Patient Stories, Expert Interviews

Targeted Therapy | Cancer FAQ, Patient Stories

Targeted therapy is a type of cancer treatment also known as precision medicine and molecularly-targeted drugs/therapies. There’s been growing focus on targeted therapy as a major part of precision medicine, which diagnoses and treats individuals based largely on their genes and proteins. It can also be used to prevent disease.

This type of treatment refers to drugs that stop the growth and spread of cancer by disrupting or interfering with “molecular targets.” These molecules are involved in the cancer growth and spread.

Below, find answers to popular targeted therapy questions and experiences of targeted therapy shared by The Patient Story community.


Targeted Therapy FAQ

How is targeted therapy different from chemotherapy?

There are several major differences between targeted therapy and chemotherapy, including (but not limited to):

  • Targeted therapies impact specific molecules (or molecular targets) linked to cancer, while standard chemotherapies impact all rapidly-dividing normal and cancerous cells.
  • Targeted therapies are chosen for how they interact with the specific molecules linked to cancer, while standard chemotherapies are typically selected for killing cells.
  • Targeted therapies are usually designed to block or stop tumor cell growth, while standard chemotherapies kill tumor cells.
How much research is being done on targeted therapy?

The Food and Drug Administration (FDA) has approved many targeted therapies in the treatment of specific cancer types.

Others are still in clinical trials, research studies involving people. Many more are still in what’s known as preclinical testing, research studies using animals.

How are targets for targeted cancer therapies identified and developed?

The starting point in developing targeted therapies is identifying the molecular targets that push cancer cell growth and help cancer cells survive. You can read more about that here.

Different types of targeted therapies in cancer treatment

There are multiple targeted therapies that have already been approved for cancer treatment, including:

  • Hormone therapies: Certain tumors are hormone-sensitive, using hormones to grow. Hormone therapies prevent the body from creating or interrupt the hormones. This applies namely to breast cancer and prostate cancer.
  • Small-molecule drugs: These are drugs that interfere with the growth and spread of cancer cells. One example is an angiogenesis inhibitor, which starves tumors by stopping the formation of new blood vessels in the tissue around them.
  • Monoclonal antibodies (that deliver toxic molecules): They block a specific target that is on the outside of cancer cells and can deliver toxic substances targeted to cancer cells. These are also a type of immunotherapy.
  • Immunotherapies: This type of treatment uses the immune system to destroy cancer cells. Drugs and antibodies sometimes bind to some immune cells to help destroy cancer cells.
Side effects of targeted therapies

There are some common side effects associated with targeted therapies:

  • Diarrhea
  • Liver problems (hepatitis, elevated liver enzymes)
  • High blood pressure
  • Blood clotting, trouble with wound healing
  • Skin problems (dry skin, rashes that look like acne, nail changes, hair color loss)
  • Gastrointestinal perforation (rare)

The good news for people who experience a lot of side effects is that some targeted therapy-related side effects have been associated with better patient outcomes.

One example according to the NCI is “patients who develop acneiform rash (skin eruptions that resemble acne) while being treated with the signal transduction inhibitors erlotinib (Tarceva®) or gefitinib (Iressa®), both of which target the epidermal growth factor receptor, have tended to respond better to these drugs than patients who do not develop the rash.”

The most common targeted therapies by cancer type

This field of cancer research is quickly growing. Here are some cancers that use targeted therapies now.

  • Breast cancer: Roughly a quarter of people with breast cancer have too much of one protein, HER2, or human epidermal growth factor receptor 2. HER2 causes the tumor cells to grow. There is targeted therapy for HER2 positive breast cancer.
  • Colorectal cancer: Some colorectal cancer patients are dealing with too much of one protein called EGFR, or epidermal growth factor receptor. There are different targeted therapies to address this.
  • Lung cancer: EGFR also applies to lung cancer, but involving different gene mutations (ALK and ROS genes). Some physicians opt to use angiogenesis inhibitors.
  • Lymphoma: For lymphoma cases, like non-Hodgkin’s and Hodgkin’s, there is an overproduction of white blood cells that fight infections (B cells). Targeted therapies work to block an enzyme that drives that overproduction. This has also been successful in treating some B-cell leukemias.
Approved target therapies by drug

The FDA has approved targeted therapies for the treatment of some patients with various types of cancer. Some are approved to treat more than one cancer. Below are some of the more popular targeted therapies:

  • Anastrozole (Arimidex®): Breast cancer
  • Axicabtagene ciloleucel (Yescarta™): Lymphoma,
  • Bevacizumab (Avastin®): Brain cancer, cervical cancer, colorectal cancer, kidney cancer, liver and bile duct cancer, lung cancer, ovarian epithelial/fallopian tube/primary peritoneal cancers
  • Blinatumomab (Blincyto®): Leukemia
  • Carfilzomib (Kyprolis®): Multiple myeloma
  • Daratumumab (Darzalex™): Multiple myeloma
  • Ibrutinib (Imbruvica®): Leukemia
  • Ipilimumab (Yervoy®): Colorectal cancer, kidney cancer, lung cancer, skin cancer
  • Nivolumab (Opdivo): Bladder cancer, colorectal cancer, esophageal cancer, head and neck cancer, kidney cancer, liver and bile duct cancer, lung cancer, skin cancer
  • Pembrolizumab (Keytruda): Bladder cancer, cervical cancer, endometrial cancer, esophageal cancer, head and neck cancer, kidney cancer, liver and bile duct cancer, lung cancer, lymphoma, skin cancer, stomach (gastric) cancer
  • Pertuzumab (Perjeta®): Breast cancer,
  • Rituximab (Rituxan®): Leukemia, lymphoma
  • Tamoxifen (Nolvadex): Breast cancer
  • Tisagenlecleucel (Kymriah®): Lymphoma,
  • Trastuzumab (Herceptin®): Breast cancer, esophageal cancer, stomach (gastric) cancer
  • Venetoclax (Venclexta™): Leukemia, lymphoma

The National Cancer Institute provides a comprehensive list here.

Targeted Therapy Stories and Experiences

Kyprolis (carfilzomib)
Multiple Myeloma Stories: IgG Lambda, Heavy Chain, Stage 3 |  Scott’s Patient Story

Scott C., Multiple Myeloma, IgG Lambda, Stage 3



Diagnosis: Multiple myeloma, IgG lambda
Cancer Details:
Early stage multiple myeloma usually causes vague symptoms, making it difficult to diagnose
1st Symptoms:
Pain in hips and ribs, night sweats, weight loss, nausea
Treatment:
Clinical trial, chemo, kyphoplasty, stem cell transplant
...
Multiple Myeloma Patient Stories: Relapsed/Refractory

Clay D., Multiple Myeloma



Diagnosis: Multiple myeloma
Cancer Details:
Early stage multiple myeloma usually causes vague symptoms, making it difficult to diagnose
1st Symptoms:
Persistent kidney issues, nausea
Treatment:
chemo, radiation, stem cell transplant
...
Velcade
Mantle Cell Lymphoma Stories: Stage 4, Non-Hodgkin’s Lymphoma | Shari’s Patient Story

Shari B., Mantle Cell Lymphoma (MCL), Stage 4



1st Symptoms: None, lymphoma discovered at unrelated doctor appointment
Treatment: 6 cycles R-CHOP, 5 cycles Phase 3 trial of Velcade + Rituxan (normally for multiple myeloma), allogeneic bone marrow transplant (BMT)
...
Multiple Myeloma Stories: Active Myeloma, Stage 3 | Melissa’s Patient Story

Melissa V., Multiple Myeloma, Stage 3



Diagnosis: Multiple myeloma, stage 3
Cancer Details:
Early stage multiple myeloma usually causes vague symptoms, making it difficult to diagnose
1st Symptoms:
Frequent infections
Treatment:
IVF treatment & Chemotherapy (RVD) for 7 rounds
...
Multiple Myeloma Stories: Active Myeloma, Stage 3 | Jude’s Patient Story

Jude A., Multiple Myeloma, Stage 3



Diagnosis: Multiple myeloma, stage 3
Cancer Details:
Early stage multiple myeloma usually causes vague symptoms, making it difficult to diagnose
1st Symptoms:
Pain in back, hips and ribs; difficulty walking
Treatment:
Bilateral femoral osteotomy, reversal due to infection; chemotherapy
...
Multiple Myeloma Stories: Light Chain, Stage 2 | Carlos’ Patient Story

Carlos C., Light Chain Multiple Myeloma



Diagnosis: Multiple myeloma, light chain
Cancer Details:
Early stage multiple myeloma usually causes vague symptoms, making it difficult to diagnose
1st Symptoms:
Back pain and spasms
Treatment:
Back surgery to fuse T1 and T2, chemotherapy (RVD) and stem cell transplant
...
Xalkori (crizotinib)
Lung Cancer (Thoracic) Oncologist, Immunotherapy: Dr. D. Ross Camidge | The Patient Story

Dr. D. Ross Camidge, M.D., Ph.D.



Role: Thoracic oncologist, Director of the Thoracic Oncology Clinical Research Programs
Focus: Lung cancer, small cell (Immunotherapy), EGFR (Osimertinib), ALK (Alectinib), ROS1 (Crizotinib), BRAF (Dabrafenib & Trametinib), NTRK
Provider: Univ. of Colorado
...
Lung Cancer Stories: Non-Small Cell Lung Cancer (NSCLC), ROS1+, Stage 4 | Lisa’s Story

Lisa G., Non-Small Cell, ROS1+, Stage 4 (Metastatic)



Cancer Details: ROS1+ tends to be aggressive. It can spread to the brain and to the bones.
1st Symptoms: Persistent cough (months), coughing a little blood, high fever, night sweats
Treatment: Chemo (4 cycles), maintenance chemo (4 cycles)
...

References:

Alternatively, call NCI’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about clinical trials of targeted therapies.