Myeloproliferative Neoplasms (MPNs)

Myeloproliferative Neoplasms (MPNs)

Patient Stories & MPN Specialist Interviews

Myeloproliferative neoplasms, also referred to commonly as “MPNs,” comprise a group of diseases caused by the bone marrow overproducing red blood cells, white blood cells, or platelets.

Three of the most common types of MPNs are essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).

Explore below to read and watch in-depth MPN patient stories and get access to top MPN specialists, who detail the latest on emerging MPN treatments and clinical trials.

Patient Stories

Myelofibrosis patient stories

Myelofibrosis Prognosis

Learn about the MF prognostic scoring system and how a myelofibrosis prognosis can change based on risk factors and genetic mutations.


Myelofibrosis Diagnosis & Treatment

Learn about the process of a myelofibrosis diagnosis and treatment plan that is developed based on the severity of the disease.



Myelofibrosis Symptoms & Causes

Discover the genes that cause myelofibrosis and the symptoms a person with MF may experience including an enlarged spleen and stomach pain.


Myelofibrosis Overview

Read about some of the most frequently asked questions and gain a basic understanding of the disease in this myelofibrosis overview.


Andrew S.



1st Symptoms: Nosebleeds (unrelated) led to blood work, revealing high WBCs



Treatment: Clinical trial, Gazyva (obinutuxumab) and steroids, Jakafi (ruxolitinib), Inrebic (fedratinib), Reblozyl (luspatercept)

Mary L.



Diagnosis: Myelofibrosis (MPN)
1st Symptoms: Fatigue, extreme dizziness (later diagnosed as vertigo)
Treatment: Pegasys, hydroxyurea (current)

MPNs Specialist Conversations


Srdan Verstovsek, MD, PhD



Role: Director, Clinical Research Center for MPNs at MD Anderson; Section Chief, MPNs; Prof., Dept. of Leukemia
Focus: Myeloproliferative neoplasms (MPN)
Institution: MD Anderson

Ruben Mesa, MD



Role: Executive Director, Mays Cancer Center; Prof. of Medicine
Focus: Myeloproliferative neoplasms (MPN)
Institution: UT Health San Antonio MD Anderson

Myeloproliferative Neoplasm FAQs


Myelofibrosis Diagnosis & Treatment

Learn about the process of a myelofibrosis diagnosis and treatment plan that is developed based on the severity of the disease.


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Myelofibrosis Overview

Read about some of the most frequently asked questions and gain a basic understanding of the disease in this myelofibrosis overview.

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Myelofibrosis Symptoms & Causes

Discover the genes that cause myelofibrosis and the symptoms a person with MF may experience including an enlarged spleen and stomach pain.

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Essential Thrombocythemia Causes & Symptoms

Discover the gene mutations linked to the cause of essential thrombocythemia and the typical symptoms linked to the disease.

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Polycythemia Vera Skin Conditions


Learn about the impacts and causes of polycythemia vera skin. Discover treatments and lifestyle changes to help cope with PV skin.

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Polycythemia Vera Prognosis


Learn about the polycythemia vera prognosis and the factors that impact the life-expectancy of a patient with PV.


Polycythemia Vera Prognosis


Learn about the polycythemia vera prognosis and the factors that impact the life-expectancy of a patient with PV.

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Polycythemia Vera Diagnosis & Treatment

Polycythemia vera can be a difficult disease to diagnose. Learn more about how doctors diagnose PV and the associated treatment plans.

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Polycythemia Vera Symptoms & Causes

Learn about the symptoms & causes behind polycythemia vera. This includes impacts of the JAK2 mutation and potential complications.

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Essential Thrombocythemia Overview

Essential thrombocythemia (ET) is a rare form of blood cancer. Learn more about the ET and FAQs about the disease.

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Polycythemia Vera Overview

Polycythemia Vera (PV) is a rare, chronic blood disorder. Learn more about PV and frequently asked questions about the disease.

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Overview of MPN Treatments



There are a wide variety of myeloproliferative disorders treatments available to help treat the various symptoms of different MPNs.
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What Are Myeloproliferative Neoplasms (MPN)?



Learn the basics of what myeloproliferative neoplasms or MPNs are, who's at highest risk, the cause of MPNs, and more.
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Myelofibrosis
Explore myelofibrosis

Myelofibrosis is a rare cancer of the bone marrow. Learn more about myleofibrosis symptoms, diagnosis, treatment and more.

Polycythemia Vera
Explore polycythemia vera

Polycythemia vera (PV) is a rare, chronic blood disorder. Learn more about polycythemia vera symptoms, diagnosis, treatment and more.

Essential Thrombocythemia
Explore essential thrombocythemia

Essential thrombocythemia (ET) is a rare form of blood cancer in which the bone marrow overproduces platelets. Learn more about essential thrombocythemia symptoms, diagnosis, treatment and more.